Article

Transcriptional targets of senataxin and E2 promoter binding factors are associated with neuro-degenerative pathways during increased autophagic flux

2022-04-07

Abstract excerpt

Autophagy is an intracellular recycling process that degrades harmful molecules, maintains optimal composition of cellular organelles and enables survival during starvation. Previous studies have demonstrated how transcription factors (TFs) can increase autophagy with therapeutic potential (impaired autophagy in the ageing brain, in particular, may be an important risk factor for dementia). To investigate the tran...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0258c6bb-1065-5124-8b77-f9b0821dae07
DOI: 10.1101/2022.04.06.486307

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transcriptional targets of senataxin and E2 promoter binding factors are associated with neuro-degenerative pathways during increased autophagic fluxDOI 10.1101/2022.04.06.486307Read

Therapeutic Potential of Vital Transcription Factors in Alzheimer’s and Parkinson’s Disease With Particular Emphasis on Transcription Factor EB Mediated AutophagySemantic proximity Read

The regulatory mechanism and therapeutic potential of transcription factor <scp>EB</scp> in neurodegenerative diseasesSemantic proximity Read

SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulationSemantic proximity Read

Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genesSemantic proximity Read

Autophagy Regulatory Network — A systems-level bioinformatics resource for studying the mechanism and regulation of autophagySemantic proximity Read

TFEB Transcriptional Responses Reveal Negative Feedback by BHLHE40 and BHLHE41Semantic proximity Read

Novel Insight into Functions of Transcription Factor EB (TFEB) in Alzheimer’s Disease and Parkinson’s DiseaseSemantic proximity Read

From the regulatory mechanism of TFEB to its therapeutic implicationsSemantic proximity Read

Systems biology of the autophagy-lysosomal pathwaySemantic proximity Read

Autophagy mediators (FOXO1, SESN3 and TSC2) in Lewy body disease and agingSemantic proximity Read

TFEB regulates autophagy: An integrated coordination of cellular degradation and recycling processesSemantic proximity Read

Decreased MEF2A Expression Regulated by Its Enhancer Methylation Inhibits Autophagy and May Play an Important Role in the Progression of Alzheimer’s DiseaseSemantic proximity Read