Compartmental structure in the secondary lymphoid tissue can slow down <i>in vivo</i> HIV-1 evolution in the presence of strong CTL responses

Abstract excerpt

Human immunodeficiency virus (HIV-1) replicates in the secondary lymphoid tissues, which are characterized by complex compartmental structures. While Cytotoxic T lymphocytes (CTL) readily access infected cells in the extrafollicular compartments, they do not home to follicular compartments, which thus represent an immune-privileged site. Using mathematical models, we have previously shown that this compartmental t...

Topics

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• Evolution, Molecular
• HIV-1
• HIV Infections
• HIV Research and Treatment
• Lymphoid Tissue
• Models, Immunological
• Mutation
• T-Lymphocytes, Cytotoxic

Identifiers and source

Literature Corpus work

023a4ab8-8d78-512c-b885-40528fcc8442

DOI

10.1101/2024.06.24.600465