Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Compartmental structure in the secondary lymphoid tissue can slow down in vivo HIV-1 evolution in the presence of strong CTL responses.

Journal of the Royal Society, Interface - 1 Feb 2025

Chung Wen-Jian, Wodarz Dominik

Abstract excerpt

Human immunodeficiency virus (HIV-1) replicates in the secondary lymphoid tissues, which are characterized by complex compartmental structures. While cytotoxic T lymphocytes (CTL) readily access infected cells in the extrafollicular compartments, they do not home to follicular compartments, which thus represent an immune-privileged site. Using mathematical models, previous work has shown that this compartmental...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Evolution, Molecular
Share to HIV-1
Share to HIV Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphoid Tissue

Share to Models, Immunological

Share to Mutation

Share to T-Lymphocytes, Cytotoxic

Source

Open in PubMed Open full text

Identifiers

PMID: 39999881
DOI: 10.1098/rsif.2024.0468
PMCID: PMC11858754

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Compartmental structure in the secondary lymphoid tissue can slow down in vivo HIV-1 evolution in the presence of strong CTL responses.PMID 39999881Read ↗

Compartmental structure in the secondary lymphoid tissue can slow down <i>in vivo</i> HIV-1 evolution in the presence of strong CTL responsesSemantic proximity Read ↗

Large Variations in HIV-1 Viral Load Explained by Shifting-Mosaic Metapopulation DynamicsSemantic proximity Read ↗

A quantitative quasispecies theory-based model of virus escape mutation under immune selection.Semantic proximity Read ↗

Ongoing HIV replication in lymph node sanctuary sites in treated patients contributes to the total latent HIV at a very slow rateSemantic proximity Read ↗

Probing the compartmentalization of HIV-1 in the central nervous system through its neutralization propertiesSemantic proximity Read ↗

HIV persistence in lymph nodesSemantic proximity Read ↗

Virus dynamic behavior of a stochastic HIV/AIDS infection model including two kinds of target cell infections and CTL immune responsesSemantic proximity Read ↗

Genetic drift and within-host metapopulation dynamics of HIV-1 infectionSemantic proximity Read ↗

High resolution spatio-temporal assessment of simian/human immunodeficiency virus (SHIV) evolution reveals a highly dynamic process within the hostSemantic proximity Read ↗

Multiple HIV-1 infection of cells and the evolutionary dynamics of cytotoxic T lymphocyte escape mutants.Semantic proximity Read ↗

Compartmentalization and clonal amplification of HIV-1 variants in the cerebrospinal fluid during primary infection.Semantic proximity Read ↗

Contribution of Follicular Dendritic Cells to Persistent HIV ViremiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.