Article

Human iPSC-derived spinal neurons carrying the ALS FUS (P525L) mutation exhibit lower response to inhibitory neurotransmitters

2025-11-04

Abstract excerpt

<title>Abstract</title> <p> Amyotrophic lateral sclerosis (ALS) is a progressive neuromuscular disorder characterized by motoneurons degeneration. Functional studies have linked ALS to hyperexcitability and excitotoxicity, but the cause of the disease is unknown, though familial ALS cases are linked to pathogenic variants in several genes, including <italic>SOD1</italic> , <italic>TARDBP</italic> and <itali...

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Literature Corpus work: 02292f1a-aa53-523d-8047-a3f50e09b76b
DOI: 10.21203/rs.3.rs-7759662/v1

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