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Low<i>IGFBP7</i>expression identifies a subset of breast cancers with favorable prognosis and sensitivity to IGF-1 receptor targeting with ganitumab: Data from I-SPY2 and SCAN-B

2023-12-18

Abstract excerpt

There has been a long-standing interest in targeting the insulin-like growth factor-1 receptor (IGF-1R) signaling system in breast cancer due to its key role in neoplastic proliferation and survival. However, no IGF-1R targeting agent has shown substantial clinical benefit in controlled trials, and no treatment predictive biomarkers for IGF-1R targeting agents exist. IGFBP7 is an atypical insulin-like growth facto...

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Literature Corpus work
020ff013-7ba7-547f-99bb-6b9ba88c0180
DOI
10.1101/2023.12.18.23300129
Open publication

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Low<i>IGFBP7</i>expression identifies a subset of breast cancers with favorable prognosis and sensitivity to IGF-1 receptor targeting with ganitumab: Data from I-SPY2 and SCAN-BDOI 10.1101/2023.12.18.23300129
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