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Article

Molecular and Clinical Portrait of HER2-low Invasive Lobular Carcinomas.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 May 2024

Djerroudi Lounes, El Sabeh-Ayoun Ahmad, Benoist Camille, Pierron Gaelle, Masliah-Planchon Julien, Fuhrmann Laetitia, Kieffer Yann, Carton Matthieu, Ramtohul Toulsie, Callens Celine, Renault Victor, Bidard François-Clément, Mechta-Grigoriou Fatima, Vincent-Salomon Anne

Abstract excerpt

Invasive lobular carcinomas (ILCs) have a low frequency of ERBB2 amplification, therefore restricting the use of conventional anti-HER2 therapies for this histologic special type. Conversely, ILCs with low HER2 overexpression may represent a broader target for the use of emerging antibody drug conjugate therapies targeting HER2, since these treatments have proven effective in HER2-low breast cancers. Very scarce...

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Identifiers

PMID: 38428737
DOI: 10.1016/j.modpat.2024.100463

Genes

ERBB2
ERBB3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Molecular and Clinical Portrait of HER2-low Invasive Lobular Carcinomas.PMID 38428737Read ↗

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