Article

A novel mutation in the nucleoporin NUP35 causes murine degenerative colonic smooth muscle myopathy

2016-01-13

Abstract excerpt

Chronic Intestinal Pseudo-Obstruction (CIPO) is a rare, but life-threatening, disease characterized by severe intestinal dysmotility. Histopathological studies of CIPO patients have identified several different mechanisms that appear to be responsible for the dysmotility, including defects in neurons, smooth muscle or interstitial cells of Cajal. Currently there are few mouse models of the various forms of CIPO. W...

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Literature Corpus work: c963c87f-405c-532f-83f1-459b4c9d1e7f
DOI: 10.1101/036582

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