Article

A 5-Lipoxygenase Inhibitor, Zileuton, Modulates Host-Immune Responses and Improves Lung Function in a Model of Severe Acute Respiratory Syndrome (SARS) Induced by <i>Betacoronavirus</i>

2023-09-19

Abstract excerpt

Exacerbated inflammatory responses are a hallmark of severe coronavirus disease 2019 (COVID-19). Zileuton (Zi) is a selective inhibitor of 5-lipoxygenase, an enzyme involved in the production of several inflammatory/pro-resolving lipid mediators. Herein, we investigated the effect of Zi treatment in a severe acute respiratory syndrome (SARS) model. Mouse hepatitis virus (MHV)3-infected mice treated with Zi signifi...

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Literature Corpus work: 017381e0-c886-5d81-bb49-acb2ab9d3f1b
DOI: 10.20944/preprints202309.1267.v1

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A 5-Lipoxygenase Inhibitor, Zileuton, Modulates Host-Immune Responses and Improves Lung Function in a Model of Severe Acute Respiratory Syndrome (SARS) Induced by <i>Betacoronavirus</i>DOI 10.20944/preprints202309.1267.v1Read

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