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RECON gene disruption enhances host resistance to enable genome-wide evaluation of intracellular pathogen fitness during infection

2024-01-16

Abstract excerpt

Transposon sequencing (Tn-seq) is a powerful genome-wide technique to assess bacterial fitness under varying growth conditions. However, screening via Tn-seq in vivo is challenging. Dose limitations and host restrictions create bottlenecks that diminish the transposon mutant pool being screened. Here we have developed a murine model with a disruption in Akr1c13 that renders the resulting RECON -/- mouse resista...

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Identifiers and source

Literature Corpus work
014b035d-fbef-5ac9-a161-59d973308956
DOI
10.1101/2024.01.15.575726
Open publication

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RECON gene disruption enhances host resistance to enable genome-wide evaluation of intracellular pathogen fitness during infectionDOI 10.1101/2024.01.15.575726
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