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Article

Overexpression of parkin protects retinal ganglion cells in experimental glaucoma

24 Jan 2018

Abstract excerpt

Glaucoma is a leading cause of irreversible blindness and characterized by progressive damage of retinal ganglion cells (RGCs). Growing evidences have linked impaired mitophagy with neurodegenerative diseases, while the E3 ubiquitin ligase parkin may play a key role. However, the pathophysiological relationship between parkin and glaucoma remains largely unknown. Using chronic hypertensive glaucoma rats induced...

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PMID: 29367744
DOI: 10.1038/s41419-017-0146-9

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