Article

BODIPY-Tagged β-Lactams as Selective Quenched Activity-Based Probes to Target Human Neutrophil Elastase

2026-03-22

Abstract excerpt

Activity-based probes are indispensable tools for interrogating protease function, and quenched fluorescent variants enable dynamic, real-time imaging of enzymatic activity. Despite these advances, very few quenched activity-based probes (qABPs) have been reported for serine proteases, which constitute the largest and most diverse mechanistic class of proteases. β -Lactams have been extensively used to develop mo...

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Literature Corpus work: 001382ef-27c6-5363-b148-3a43c4fa94a9
DOI: 10.64898/2026.03.19.712884

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