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Article

Polyol-induced activation by excess substrate of the D70G butyrylcholinesterase mutant.

Biochimica et biophysica acta - 11 Jan 1999

Levitsky V, Xie W, Froment M T, Lockridge O, Masson P

Abstract excerpt

Wild-type human butyrylcholinesterase (BuChE) has a non-Michaelian behaviour showing substrate activation with butyrylthiocholine (BTC) as the substrate. The D70G mutant has a catalytic constant identical to that of the wild-type enzyme, but a 10-fold lower affinity for BTC compared to wild-type enzyme, and it does not exhibit activation by excess BTC under conventional conditions. In the present work it was...

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Source

Identifiers

PMID: 9989227
DOI: 10.1016/s0167-4838(98)00253-2

Genes

BTC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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