Role of aspartate 70 and tryptophan 82 in binding of succinyldithiocholine to human butyrylcholinesterase.

doi:10.1021/bi962484a

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Article

Role of aspartate 70 and tryptophan 82 in binding of succinyldithiocholine to human butyrylcholinesterase.

Biochemistry - 25 Feb 1997

Masson P, Legrand P, Bartels C F, Froment M T, Schopfer L M, Lockridge O

Abstract excerpt

The atypical variant of human butyrylcholinesterase has Gly in place of Asp 70. Patients with this D70G mutation respond abnormally to the muscle relaxant succinyldicholine, experiencing hours of apnea rather than the intended 3 min. Asp 70 is at the rim of the active site gorge 12 A from the act...

Topics

Aspartic Acid
Butyrylcholinesterase
Humans
Kinetics
Mutation
Protein Conformation
Recombinant Proteins
Succinylcholine
Tryptophan

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