Article
Thyroid hormones induce features of the hypertrophic phenotype and stimulate correlates of CPPD crystal formation in articular chondrocytes.
The Journal of rheumatology - 1 Feb 1999
Rosenthal A K, Henry L A
Abstract excerpt
OBJECTIVE: Articular cartilage affected by calcium pyrophosphate dihydrate (CPPD) crystal deposition contains abnormal chondrocytes with morphologic similarities to the terminally differentiated hypertrophic chondrocytes that mineralize in growth plate cartilage. These chondrocytes also elaborate...
Topics
- Alkaline Phosphatase
- Animals
- Binding Sites
- Calcium Pyrophosphate
- Cell Differentiation
- Cell Size
- Cells, Cultured
- Chondrocalcinosis
- Chondrocytes
- Collagen
- Diphosphates
- Phenotype
- Pyrophosphatases
- Swine
- Thymidine
- Thyroxine
- Transforming Growth Factor beta
- Triiodothyronine