Article
Global sequence diversity of BRCA2: analysis of 71 breast cancer families and 95 control individuals of worldwide populations.
Human molecular genetics - 1 Mar 1999
Wagner T M, Hirtenlehner K, Shen P, Moeslinger R, Muhr D, Fleischmann E, Concin H, Doeller W, Haid A, Lang A H, Mayer P, Petru E, Ropp E, Langbauer G, Kubista E, Scheiner O, Underhill P, Mountain J, Stierer M, Zielinski C, Oefner P
Abstract excerpt
The aim of this study was to evaluate the prevalence of simple sequence variation in the BRCA2 gene. To this end, 71 breast and breast-ovarian cancer (HBC/HBOC) families along with 95 control individuals from a wide range of ethnicities were analyzed by means of denaturing high-performance liquid...
Topics
- Africa
- BRCA2 Protein
- Base Sequence
- Breast Neoplasms
- DNA Mutational Analysis
- DNA Primers
- Female
- Gene Frequency
- Genes, Tumor Suppressor
- Genetic Variation
- Humans