Article
EGF promotes development of a differentiated trophoblast phenotype having c-myc and junB proto-oncogene activation.
Placenta - 1 Jan 1999
Dakour J, Li H, Chen H, Morrish D W
Abstract excerpt
Human placental cytotrophoblast cells differentiate by a process of fusion into a syncytium. This process is stimulated by EGF but also occurs spontaneously at a slower rate in cultured cytotrophoblast cells. To determine nuclear proto-oncogene changes mediating these events, c-myc, c-fos, c-jun and junB were measured in spontaneously differentiating cells and in cells exposed to EGF. c-myc showed a transient...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.