Article
EGF promotes development of a differentiated trophoblast phenotype having c-myc and junB proto-oncogene activation.
Placenta - 1 Jan 1999
Dakour J, Li H, Chen H, Morrish D W
Abstract excerpt
Human placental cytotrophoblast cells differentiate by a process of fusion into a syncytium. This process is stimulated by EGF but also occurs spontaneously at a slower rate in cultured cytotrophoblast cells. To determine nuclear proto-oncogene changes mediating these events, c-myc, c-fos, c-jun...
Topics
- Cell Adhesion
- Cell Differentiation
- Cell Division
- Cells, Cultured
- Epidermal Growth Factor
- Female
- Fluorescent Antibody Technique
- Gene Expression
- Genes, fos
- Genes, jun
- Genes, myc
- Glycoprotein Hormones, alpha Subunit
- Humans
- Kinetics
- Phenotype
- Pregnancy
- Proto-Oncogene Mas
- RNA, Messenger