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Article

Cyclic AMP-dependent protein kinases and human trophoblast cell differentiation in vitro

1 Apr 1998

Abstract excerpt

Human trophoblast cells offer a unique in vitro model for the study of aspects of the dynamic processes occurring during cell fusion and syncytium formation. In the human placenta, mononuclear cytotrophoblasts aggregate and fuse to form a multinucleated syncytiotrophoblast. In vitro, the addition of cyclic AMP analogs, 8-bromo-cyclic-AMP or Sp-8-bromo-cyclic AMPS, promotes syncytiotrophoblast formation, as shown...

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PMID: 9490643
DOI: 10.1242/jcs.111.7.995

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