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The t(1;9)(p34;q34) and t(8;12)(p11;q15) fuse pre‐mRNA processing proteins <i>SFPQ (PSF)</i> and <i>CPSF6</i> to <i>ABL</i> and <i>FGFR1</i>

18 Jan 2008

Abstract excerpt

We have investigated two patients with acquired chromosomal rearrangements, a male presenting with a t(1;9)(p34;q34) and B cell progenitor acute lymphoid leukemia and a female presenting with a t(8;12)(p11;q15) and the 8p11 myeloproliferative syndrome. We determined that the t(1;9) fused ABL to SFPQ (also known as PSF), a gene mapping to 1p34 that encodes a polypyrimidine tract-binding protein-associated splicing...

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PMID: 18205209
DOI: 10.1002/gcc.20541

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The t(1;9)(p34;q34) and t(8;12)(p11;q15) fuse pre‐mRNA processing proteins <i>SFPQ (PSF)</i> and <i>CPSF6</i> to <i>ABL</i> and <i>FGFR1</i>PMID 18205209Read ↗

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FGFR1 is fused to the centrosome-associated proteinCEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9)(p12;q33)Semantic proximity Read ↗

The t(1;9)(p34;q34) fusing ABL1 with SFPQ, a pre-mRNA processing gene, is recurrent in acute lymphoblastic leukemiasSemantic proximity Read ↗

Fusion of the <i>BCR</i> and the fibroblast growth factor receptor‐1 (<i>FGFR1</i>) genes as a result of t(8;22)(p11;q11) in a myeloproliferative disorder: The first fusion gene involving <i>BCR</i> but not <i>ABL</i>Semantic proximity Read ↗

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