Article
A PstI polymorphism detects the mutation of serine128 to arginine in CD 62E gene - a risk factor for coronary artery disease.
Journal of biomedical science - 1 Jan 1999
Ye S Q, Usher D, Virgil D, Zhang L Q, Yochim S E, Gupta R
Abstract excerpt
The mutation of serine128 to arginine in the CD 62E gene is a risk factor for coronary artery disease (CAD). We designed a new method to detect this mutation based on the observation that it is due to a transversion of nucleotide A561 to C, which abolishes a PstI recognition site. Two alleles, A...
Topics
- Alleles
- Amino Acid Substitution
- Angiography
- Arginine
- Coronary Disease
- DNA Mutational Analysis
- Deoxyribonucleases, Type II Site-Specific
- E-Selectin
- Exons
- Female
- Gene Frequency
- Heterozygote
- Humans
- Male
- Middle Aged
- Mutation
- Polymorphism, Genetic
- Reference Values