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Article

HIRA, a DiGeorge syndrome candidate gene, is required for cardiac outflow tract septation.

Circulation research - 5 Feb 1999

Farrell M J, Stadt H, Wallis K T, Scambler P, Hixon R L, Wolfe R, Leatherbury L, Kirby M L

Abstract excerpt

DiGeorge syndrome (DGS) is a congenital disease characterized by defects in organs and tissues that depend on contributions by cell populations derived from neural crest for proper development. A number of candidate genes that lie within the q11 region of chromosome 22 commonly deleted in DGS patients have been identified. Orthologues of the DGS candidate gene HIRA are expressed in the neural crest and in neural...

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Source

Identifiers

PMID: 9933243
DOI: 10.1161/01.res.84.2.127

Genes

HIRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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HIRA, a DiGeorge syndrome candidate gene, is required for cardiac outflow tract septation.PMID 9933243Read ↗

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Sonic hedgehog is required for cardiac outflow tract and neural crest cell developmentSemantic proximity Read ↗

Targeted mutagenesis of the Hira gene results in gastrulation defects and patterning abnormalities of mesoendodermal derivatives prior to early embryonic lethality.Semantic proximity Read ↗

A heart segmental defect in the anterior-posterior axis of a transgenic mutant mouse.Semantic proximity Read ↗

A human homolog of the S.cerevisiae HIR1 and HIR2 transcriptional repressors cloned from the DiGeorge syndrome critical regionSemantic proximity Read ↗

ZNF74, a gene deleted in DiGeorge syndrome, is expressed in human neural crest-derived tissues and foregut endoderm epithelia.Semantic proximity Read ↗

De novo start-loss variant in HIRA in patient with DiGeorge-like syndrome.Semantic proximity Read ↗

Decreased embryonic retinoic acid synthesis results in a DiGeorge syndrome phenotype in newborn mice.Semantic proximity Read ↗

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