Article
Identification of differential proteins in nasopharyngeal carcinoma cells with p53 silence by proteome analysis.
FEBS letters - 9 Jan 2007
Sun Yi, Yi Hong, Zhang Peng-Fei, Li Mao-Yu, Li Cui, Li Feng, Peng Fang, Feng Xue-Ping, Yang Yi-Xuan, Yang Fang, Xiao Zhi-Qiang, Chen Zhu-Chu
Abstract excerpt
Although mutation of p53 tumor-suppressor gene is rare in nasopharyngeal carcinoma (NPC), NPC has a high frequency of overexpression of p53 protein. There seem to be complex mechanisms of inactivation and stabilization of p53 in NPC. To detect proteins associated with the function of p53 in high throughout screening, we succeeded in establishing p53 knockdown human NPC CNE2 cell line (CNE2sip53) using stable RNA...
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