Metamorphosis is inhibited in transgenic Xenopus laevis tadpoles that overexpress type III deiodinase.

doi:10.1073/pnas.96.3.962

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Article

Metamorphosis is inhibited in transgenic Xenopus laevis tadpoles that overexpress type III deiodinase.

Proceedings of the National Academy of Sciences of the United States of America - 2 Feb 1999

Huang H, Marsh-Armstrong N, Brown D D

Abstract excerpt

One of the genes that is up-regulated by thyroid hormone (TH) during Xenopus laevis metamorphosis encodes a type III deiodinase (D3) that inactivates TH. Transgenic X. laevis tadpoles overexpressing a GFP-D3 fusion protein were produced. These transgenic tadpoles had high levels of deiodinase act...

Topics

Animals
Animals, Genetically Modified
Cartilage
Enzyme Induction
Green Fluorescent Proteins
Iodide Peroxidase
Luminescent Proteins
Metamorphosis, Biological
Phenotype
Recombinant Fusion Proteins
Tyrosine 3-Monooxygenase
Xenopus laevis

Source

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Identifiers

PMID: 9927676
DOI: 10.1073/pnas.96.3.962
PMCID: PMC15333

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9927676-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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