Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Metamorphosis is inhibited in transgenic Xenopus laevis tadpoles that overexpress type III deiodinase.

Proceedings of the National Academy of Sciences of the United States of America - 2 Feb 1999

Huang H, Marsh-Armstrong N, Brown D D

Abstract excerpt

One of the genes that is up-regulated by thyroid hormone (TH) during Xenopus laevis metamorphosis encodes a type III deiodinase (D3) that inactivates TH. Transgenic X. laevis tadpoles overexpressing a GFP-D3 fusion protein were produced. These transgenic tadpoles had high levels of deiodinase activity and were resistant to exogenous TH added 1 week after fertilization. They developed normally throughout...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Cartilage

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Enzyme Induction

Share to Green Fluorescent Proteins

Share to Phenotype

Share to Recombinant Fusion Proteins

Share to Tyrosine 3-Monooxygenase

Share to Xenopus laevis

Source

Open in PubMed Open full text

Identifiers

PMID: 9927676
DOI: 10.1073/pnas.96.3.962
PMCID: PMC15333

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Metamorphosis is inhibited in transgenic Xenopus laevis tadpoles that overexpress type III deiodinase.PMID 9927676Read ↗

Knockdown of type 3 iodothyronine deiodinase severely perturbs both embryonic and early larval development in zebrafish.Semantic proximity Read ↗

Deiodinase Activity Is Present in<i>Xenopus laevis</i>during Early EmbryogenesisSemantic proximity Read ↗

Role of Thyroid Hormone Receptor in Amphibian Development.Semantic proximity Read ↗

Organ-Specific Requirements for Thyroid Hormone Receptor Ensure Temporal Coordination of Tissue-Specific Transformations and Completion of Xenopus MetamorphosisSemantic proximity Read ↗

Thyroid Hormone Receptor Is Essential for Larval Epithelial Apoptosis and Adult Epithelial Stem Cell Development but Not Adult Intestinal Morphogenesis during Xenopus tropicalis MetamorphosisSemantic proximity Read ↗

Life Without Thyroid Hormone ReceptorSemantic proximity Read ↗

Growth, Development, and Intestinal Remodeling Occurs in the Absence of Thyroid Hormone Receptor α in Tadpoles of Xenopus tropicalis.Semantic proximity Read ↗

Xenopus laevis as a model for studying thyroid hormone signalling: From development to metamorphosisSemantic proximity Read ↗

A Rapid, Physiologic Protocol for Testing Transcriptional Effects of Thyroid-Disrupting Agents in Premetamorphic Xenopus TadpolesSemantic proximity Read ↗

Transgenic Analysis Reveals that Thyroid Hormone Receptor Is Sufficient To Mediate the Thyroid Hormone Signal in Frog MetamorphosisSemantic proximity Read ↗

Type 3 deiodinase is critical for the maturation and function of the thyroid axis.Semantic proximity Read ↗

Xenopus metamorphosis as a model to study thyroid hormone receptor function during vertebrate developmental transitionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.