Growth, Development, and Intestinal Remodeling Occurs in the Absence of Thyroid Hormone Receptor α in Tadpoles of Xenopus tropicalis.

doi:10.1210/en.2016-1955

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Article

Growth, Development, and Intestinal Remodeling Occurs in the Absence of Thyroid Hormone Receptor α in Tadpoles of Xenopus tropicalis.

Endocrinology - 1 Jun 2017

Choi Jinyoung, Ishizuya-Oka Atsuko, Buchholz Daniel R

Abstract excerpt

During development in all vertebrates, thyroid hormone receptors (TRs) are expressed before as well as during and after the peak in plasma thyroid hormone (TH) levels. Previously, we established a role for unliganded TRα in gene repression and developmental timing using tadpoles of TRα knockout (TRαKO) frogs. Here, we examined the role of liganded TRα on growth, development, and intestinal remodeling during...

Topics

Animals
Animals, Genetically Modified
Fertility
Gene Expression Regulation, Developmental
Gene Knockout Techniques
Intestines
Larva
Metamorphosis, Biological
Phenotype
Thyroid Hormone Receptors alpha
Xenopus

Source

Open in PubMed

Identifiers

PMID: 28323943
DOI: 10.1210/en.2016-1955

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