Article
Concept of lymphoid versus myeloid dendritic cell lineages revisited: both CD8alpha(-) and CD8alpha(+) dendritic cells are generated from CD4(low) lymphoid-committed precursors.
Blood - 1 Oct 2000
Martín P, del Hoyo G M, Anjuère F, Ruiz S R, Arias C F, Marín A R, Ardavín C
Abstract excerpt
Two dendritic cell (DC) subsets have been identified in the murine system on the basis of their differential CD8alpha expression. CD8alpha(+) DCs and CD8alpha(-) DCs are considered as lymphoid- and myeloid-derived, respectively, because CD8alpha(+) but not CD8alpha(-) splenic DCs were generated from lymphoid CD4(low) precursors, devoid of myeloid reconstitution potential. Although CD8alpha(-) DCs were first...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.