Article
Iteratively reweighted least squares mapping of quantitative trait loci.
Behavior genetics - 1 Sept 1998
Xu S
Abstract excerpt
Mapping quantitative trait loci (QTL) is a typical problem of regression with uncertain independent variables because the genotype of a putative QTL is not observed. Rather, the genotype is inferred from marker information. The method of maximum likelihood (ML) methods is considered to be the optimal solution for this problem because the distribution of the unobserved QTL genotype is fully taken into account. The...
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