Article
Statistical properties of interval mapping methods on quantitative trait loci location: impact on QTL/eQTL analyses.
BMC genetics - 20 Apr 2012
Wang Xiaoqiang, Gilbert Hélène, Moreno Carole, Filangi Olivier, Elsen Jean-Michel, Le Roy Pascale
Abstract excerpt
BACKGROUND: Quantitative trait loci (QTL) detection on a huge amount of phenotypes, like eQTL detection on transcriptomic data, can be dramatically impaired by the statistical properties of interval mapping methods. One of these major outcomes is the high number of QTL detected at marker locations. The present study aims at identifying and specifying the sources of this bias, in particular in the case of analysis...
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