Article
Crystal structure of the E166A mutant of extended-spectrum beta-lactamase Toho-1 at 1.8 A resolution.
Journal of molecular biology - 5 Feb 1999
Ibuka A, Taguchi A, Ishiguro M, Fushinobu S, Ishii Y, Kamitori S, Okuyama K, Yamaguchi K, Konno M, Matsuzawa H
Abstract excerpt
Bacterial resistance to beta-lactams is mainly due to the production of beta-lactamase. Especially through the production of extended-spectrum beta-lactamases (ESBLs), bacteria have acquired resistance not only to penicillins, but also to expanded-spectrum cephems. Here, we describe the crystal s...
Topics
- Amino Acid Sequence
- Binding Sites
- Crystallography, X-Ray
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Protein Conformation
- Sequence Homology, Amino Acid
- beta-Lactamases