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Article

Ultrahigh resolution structure of a class A beta-lactamase: on the mechanism and specificity of the extended-spectrum SHV-2 enzyme.

Journal of molecular biology - 18 Apr 2003

Nukaga Michiyoshi, Mayama Kayoko, Hujer Andrea M, Bonomo Robert A, Knox James R

Abstract excerpt

Bacterial beta-lactamases hydrolyze beta-lactam antibiotics such as penicillins and cephalosporins. The TEM-type class A beta-lactamase SHV-2 is a natural variant that exhibits activity against third-generation cephalosporins normally resistant to hydrolysis by class A enzymes. SHV-2 contains a single Gly238Ser change relative to the wild-type enzyme SHV-1. Crystallographic refinement of a model including...

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PMID: 12684014
DOI: 10.1016/s0022-2836(03)00210-9

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Ultrahigh resolution structure of a class A beta-lactamase: on the mechanism and specificity of the extended-spectrum SHV-2 enzyme.PMID 12684014Read ↗

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