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Article

Antisense oligonucleotide inhibition of hepatitis C virus (HCV) gene expression in livers of mice infected with an HCV-vaccinia virus recombinant.

Antimicrobial agents and chemotherapy - 1 Feb 1999

Zhang H, Hanecak R, Brown-Driver V, Azad R, Conklin B, Fox M C, Anderson K P

Abstract excerpt

Hepatitis C virus (HCV) is the major cause of non-A, non-B hepatitis worldwide. Current treatments are not curative for most infected individuals, and there is an urgent need for both novel therapeutic agents and small-animal models which can be used to evaluate candidate drugs. A small-animal model of HCV gene expression was developed with recombinant vaccinia virus vectors. VHCV-IRES (internal ribosome entry...

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Identifiers

PMID: 9925530
DOI: 10.1128/AAC.43.2.347
PMCID: PMC89075

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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