Article
Antisense oligonucleotide inhibition of hepatitis C virus (HCV) gene expression in livers of mice infected with an HCV-vaccinia virus recombinant.
Antimicrobial agents and chemotherapy - 1 Feb 1999
Zhang H, Hanecak R, Brown-Driver V, Azad R, Conklin B, Fox M C, Anderson K P
Abstract excerpt
Hepatitis C virus (HCV) is the major cause of non-A, non-B hepatitis worldwide. Current treatments are not curative for most infected individuals, and there is an urgent need for both novel therapeutic agents and small-animal models which can be used to evaluate candidate drugs. A small-animal mo...
Topics
- Animals
- Antiviral Agents
- Codon, Initiator
- Conserved Sequence
- Cytidine
- Dose-Response Relationship, Drug
- Female
- Gene Expression Regulation, Viral
- Genetic Vectors
- Hepacivirus
- Hepatitis C
- Liver
- Luciferases
- Mice
- Mice, Inbred BALB C