Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Down-regulation of IRES containing 5'UTR of HCV genotype 3a using siRNAs.

Virology journal - 13 May 2011

Khaliq Saba, Jahan Shah, Pervaiz Asim, Ali Ashfaq Usman, Hassan Sajida

Abstract excerpt

BACKGROUND: Hepatitis C virus (HCV) is a major causative agent of liver associated diseases leading to the development of hepatocellular carcinoma (HCC) all over the world and genotype-3a responsible for most of the cases in Pakistan. Due to the limited efficiency of current chemotherapy of interferon-α (IFN-α) and ribavirin against HCV infection alternative options are desperately needed out of which the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5' Untranslated Regions
Share to Biological Products
Share to Gene Silencing

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hepatocytes

Share to Pakistan

Share to Protein Biosynthesis

Share to RNA, Small Interfering

Share to Staining and Labeling

Source

Open in PubMed Open full text

Identifiers

PMID: 21569449
DOI: 10.1186/1743-422X-8-221
PMCID: PMC3116492

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Down-regulation of IRES containing 5'UTR of HCV genotype 3a using siRNAs.PMID 21569449Read ↗

Inhibition of hepatitis C virus genotype 3a by siRNAs targeting envelope genes.Semantic proximity Read ↗

siRNAs: Potential therapeutic agents against Hepatitis C VirusSemantic proximity Read ↗

Inhibition of Hepatitis C Virus Infection in Cell Culture by Small Interfering RNAsSemantic proximity Read ↗

Therapeutic application of RNA interference for hepatitis C virus.Semantic proximity Read ↗

Therapeutic potential of <scp>RNA</scp> interference: a new molecular approach to antiviral treatment for hepatitis <scp>C</scp>Semantic proximity Read ↗

Inhibition of full length hepatitis C virus particles of 1a genotype through small interference RNA.Semantic proximity Read ↗

shRNAs Targeting Hepatitis C: Effects of Sequence and Structural Features, and Comparision with siRNASemantic proximity Read ↗

CRISPR-Cas13a mediated targeting of hepatitis C virus internal-ribosomal entry site (IRES) as an effective antiviral strategySemantic proximity Read ↗

Consensus siRNA for inhibition of HCV genotype-4 replication.Semantic proximity Read ↗

Effect of 5'-UTR mutations on HCV replicationSemantic proximity Read ↗

Molecular characterization and fluorescence analysis of HCV non-structural proteins NS3, NS3-4A and NS4A of genotype 3a.Semantic proximity Read ↗

RNA interference blocks gene expression and RNA synthesis from hepatitis C replicons propagated in human liver cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.