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Article

Preclinical evaluation of an anti-HCV miRNA cluster for treatment of HCV infection.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Mar 2013

Yang Xiao, Marcucci Katherine, Anguela Xavier, Couto Linda B

Abstract excerpt

We developed a strategy to treat hepatitis C virus (HCV) infection by replacing five endogenous microRNA (miRNA) sequences of a natural miRNA cluster (miR-17-92) with sequences that are complementary to the HCV genome. This miRNA cluster (HCV-miR-Cluster 5) is delivered to cells using adeno-assoc...

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Identifiers

PMID: 23295950
DOI: 10.1038/mt.2012.247
PMCID: PMC3589168

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23295950-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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