Article
A germline hMSH2 alteration is unrelated to colonic microsatellite instability in patients with ulcerative colitis.
Human pathology - 1 Jan 1999
Noffsinger A E, Belli J M, Fogt F, Fischer J, Goldman H, Fenoglio-Preiser C M
Abstract excerpt
Recently, a polymorphism in the hMSH2 DNA mismatch repair gene has been associated with the development of dysplasia in ulcerative colitis (UC) patients. This polymorphism is of interest because DNA mismatch repair defects result in alterations in microsatellite stability. The current study was designed to determine whether this hMSH2 polymorphism associates with the development of microsatellite instability and...
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