Article
Pro12Ala missense mutation of the peroxisome proliferator activated receptor gamma and diabetes mellitus.
Biochemical and biophysical research communications - 19 Jan 1999
Ringel J, Engeli S, Distler A, Sharma A M
Abstract excerpt
Peroxisome proliferator activated receptor-gamma (PPARgamma) is a nuclear receptor that regulates adipocyte differentiation and possibly lipid metabolism and insulin sensitivity. Therefore, PPARgamma is a promising candidate gene for several disorders including diabetes, obesity, and dyslipoprote...
Topics
- Adult
- Alanine
- Amino Acid Substitution
- Cholesterol
- Codon
- Coronary Disease
- Diabetes Mellitus
- Diabetes Mellitus, Type 1
- Diabetes Mellitus, Type 2
- Diabetic Angiopathies
- Diabetic Retinopathy
- Female
- Gene Frequency
- Genetic Variation
- Humans
- Hyperlipidemias
- Male
- Middle Aged