Article
Pro12Ala missense mutation of the peroxisome proliferator activated receptor gamma and diabetes mellitus.
Biochemical and biophysical research communications - 19 Jan 1999
Ringel J, Engeli S, Distler A, Sharma A M
Abstract excerpt
Peroxisome proliferator activated receptor-gamma (PPARgamma) is a nuclear receptor that regulates adipocyte differentiation and possibly lipid metabolism and insulin sensitivity. Therefore, PPARgamma is a promising candidate gene for several disorders including diabetes, obesity, and dyslipoproteinemia. Screening for mutations in the entire coding region of the PPARgamma gene yielded a missense C --> G mutation...
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