Article
Psychotropic effects of dextromethorphan are altered by the CYP2D6 polymorphism: a pilot study.
Journal of clinical psychopharmacology - 1 Aug 1998
Zawertailo L A, Kaplan H L, Busto U E, Tyndale R F, Sellers E M
Abstract excerpt
Dextromethorphan is a nonopioid antitussive metabolized by cytochrome P450 2D6 (CYP2D6) to an active metabolite, dextrorphan. CYP2D6 is polymorphically expressed in humans, with 5 to 10% of Caucasians being homozygous deficient for the active form of the enzyme. In a pilot study, the authors inve...
Topics
- Adult
- Antitussive Agents
- Cytochrome P-450 CYP2D6
- Dextromethorphan
- Dose-Response Relationship, Drug
- Genotype
- Humans
- Illicit Drugs
- Male
- Metabolic Clearance Rate
- Pilot Projects
- Polymorphism, Genetic