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Article

Engineered assembly of intertwined oligomers of an immunoglobulin chain.

Journal of molecular biology - 29 Jan 1999

Hayes M V, Sessions R B, Brady R L, Clarke A R

Abstract excerpt

Domain 1 of CD2 (CD2.D1) forms a conventional Ig fold stabilised by non-covalent antiparallel contacts between beta-strands. Removing two residues from the middle of the protein sequence, where the polypeptide chain normally folds back upon itself, stabilises an open conformation. In this modifie...

Topics

Animals
CD2 Antigens
Dimerization
Immunoglobulins
In Vitro Techniques
Kinetics
Models, Molecular
Mutation
Protein Conformation
Protein Denaturation
Protein Engineering
Protein Folding

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Structure, Secondary

Rats

Recombinant Fusion Proteins

Sequence Deletion

Thermodynamics

Source

Identifiers

PMID: 9917417
DOI: 10.1006/jmbi.1998.2415

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9917417-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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