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Article

Engineered assembly of intertwined oligomers of an immunoglobulin chain.

Journal of molecular biology - 29 Jan 1999

Hayes M V, Sessions R B, Brady R L, Clarke A R

Abstract excerpt

Domain 1 of CD2 (CD2.D1) forms a conventional Ig fold stabilised by non-covalent antiparallel contacts between beta-strands. Removing two residues from the middle of the protein sequence, where the polypeptide chain normally folds back upon itself, stabilises an open conformation. In this modified molecule, the optimum evolved contacts between side-chains can only be satisfied through the antiparallel association...

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Identifiers

PMID: 9917417
DOI: 10.1006/jmbi.1998.2415

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