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Article

Crystal structure of CcdB, a topoisomerase poison from E. coli.

Journal of molecular biology - 29 Jan 1999

Loris R, Dao-Thi M H, Bahassi E M, Van Melderen L, Poortmans F, Liddington R, Couturier M, Wyns L

Abstract excerpt

The crystal structure of CcdB, a protein that poisons Escherichia coli gyrase, was determined in three crystal forms. The protein consists of a five-stranded antiparallel beta-pleated sheet followed by a C-terminal alpha-helix. In one of the loops of the sheet, a second small three-stranded antiparallel beta-sheet is inserted that sticks out of the molecule as a wing. This wing contains the LysC proteolytic...

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Identifiers

PMID: 9917404
DOI: 10.1006/jmbi.1998.2395

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