Article
Crystal structure of CcdB, a topoisomerase poison from E. coli.
Journal of molecular biology - 29 Jan 1999
Loris R, Dao-Thi M H, Bahassi E M, Van Melderen L, Poortmans F, Liddington R, Couturier M, Wyns L
Abstract excerpt
The crystal structure of CcdB, a protein that poisons Escherichia coli gyrase, was determined in three crystal forms. The protein consists of a five-stranded antiparallel beta-pleated sheet followed by a C-terminal alpha-helix. In one of the loops of the sheet, a second small three-stranded antip...
Topics
- Amino Acid Sequence
- Bacterial Proteins
- Bacterial Toxins
- Crystallography, X-Ray
- DNA Gyrase
- DNA, Bacterial
- Dimerization
- Escherichia coli
- Hydrogen Bonding
- Macromolecular Substances
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Plasmids
- Protein Conformation
- Protein Structure, Secondary
- Topoisomerase II Inhibitors