Article
The ratio between CcdA and CcdB modulates the transcriptional repression of the ccd poison-antidote system.
Molecular microbiology - 1 Jul 2001
Afif H, Allali N, Couturier M, Van Melderen L
Abstract excerpt
The ccd operon of the F plasmid encodes CcdB, a toxin targeting the essential gyrase of Escherichia coli, and CcdA, the unstable antidote that interacts with CcdB to neutralize its toxicity. Although work from our group and others has established that CcdA and CcdB are required for transcriptional repression of the operon, the underlying mechanism remains unclear. The results presented here indicate that,...
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