Article
Cell killing by the F plasmid CcdB protein involves poisoning of DNA-topoisomerase II complexes.
Journal of molecular biology - 5 Aug 1992
Bernard P, Couturier M
Abstract excerpt
In Escherichia coli, the miniF plasmid CcdB protein is responsible for cell death when its action is not prevented by polypeptide CcdA. We report the isolation, localization, sequencing and properties of a bacterial mutant resistant to the cytotoxic activity of the CcdB protein. This mutation is...
Topics
- Amino Acid Sequence
- Bacterial Proteins
- Bacterial Toxins
- Cell Death
- Cytotoxins
- DNA Damage
- DNA Gyrase
- DNA Topoisomerases, Type II
- DNA, Bacterial
- Escherichia coli
- F Factor
- Genes, Bacterial
- Macromolecular Substances
- Mutation
- Plasmids
- Protein Binding
- Recombination, Genetic
- Restriction Mapping