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Article

Cell killing by the F plasmid CcdB protein involves poisoning of DNA-topoisomerase II complexes.

Journal of molecular biology - 5 Aug 1992

Bernard P, Couturier M

Abstract excerpt

In Escherichia coli, the miniF plasmid CcdB protein is responsible for cell death when its action is not prevented by polypeptide CcdA. We report the isolation, localization, sequencing and properties of a bacterial mutant resistant to the cytotoxic activity of the CcdB protein. This mutation is located in the gene encoding the A subunit of topoisomerase II and produces an Arg462----Cys substitution in the amino...

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PMID: 1324324
DOI: 10.1016/0022-2836(92)90629-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Cell killing by the F plasmid CcdB protein involves poisoning of DNA-topoisomerase II complexes.PMID 1324324Read ↗

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