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Article

Mechanism of CcdA-Mediated Rejuvenation of DNA Gyrase.

Structure (London, England : 1993) - 5 May 2020

Aghera Nilesh K, Prabha Jyothi, Tandon Himani, Chattopadhyay Gopinath, Vishwanath Sneha, Srinivasan Narayanaswamy, Varadarajan Raghavan

Abstract excerpt

Most biological processes involve formation of transient complexes where binding of a ligand allosterically modulates function. The ccd toxin-antitoxin system is involved in plasmid maintenance and bacterial persistence. The CcdA antitoxin accelerates dissociation of CcdB from its complex with DNA gyrase, binds and neutralizes CcdB, but the mechanistic details are unclear. Using a series of experimental...

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PMID: 32294467
DOI: 10.1016/j.str.2020.03.006

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