Article
HLA-DRB1 and tumor necrosis factor gene polymorphisms in Japanese patients with multiple sclerosis.
Journal of neuroimmunology - 1 Dec 1998
Ma J J, Nishimura M, Mine H, Saji H, Ohta M, Saida K, Ozawa K, Kawakami H, Saida T, Uchiyama T
Abstract excerpt
We studied genetic polymorphisms in the tumor necrosis factor (TNF) region as well as HLA-DRB1 of 42 patients with Western-type multiple sclerosis (MS) and 38 with Asian-type MS in Japan. The sex ratio (Female:Male) was significantly higher in Asian than in Western type MS (3.8 vs. 1.3, P = 0.038...
Topics
- Adult
- Alleles
- Female
- Gene Frequency
- Genotype
- HLA-DR Antigens
- HLA-DRB1 Chains
- Humans
- Japan
- Lymphotoxin-alpha
- Male
- Microsatellite Repeats
- Multiple Sclerosis
- Polymorphism, Genetic
- Reference Values
- Tumor Necrosis Factor-alpha