Bivariate familial correlation analysis of quantitative traits by use of estimating equations: application to a familial analysis of the insulin resistance syndrome.

Abstract excerpt

Familial correlation analysis involving two traits may give a better insight into the etiology of multifactorial syndromes than familial analysis focused on single traits. Significant cross-trait correlations between biological relatives but not between spouses suggest that the two traits share common transmissible factors whereas correlations between spouses additionally suggest the influence of shared lifestyle...

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