Article
Angiotensinogen Thr235 variant is associated with abnormal physiologic change of the uterine spiral arteries in first-trimester decidua.
American journal of obstetrics and gynecology - 1 Jan 1999
Morgan T, Craven C, Lalouel J M, Ward K
Abstract excerpt
OBJECTIVE: The angiotensinogen Thr235 polymorphism associated with preeclampsia is tightly linked to a mutation in the angiotensinogen promoter A(-6), which may lead to elevated expression in decidual spiral arteries. We hypothesize that locally elevated angiotensin II levels play a role in faile...
Topics
- Alleles
- Amino Acid Sequence
- Angiotensinogen
- Arteries
- Decidua
- Female
- Genetic Variation
- Homozygote
- Humans
- Image Processing, Computer-Assisted
- Pregnancy
- Pregnancy Trimester, First
- Reference Values
- Uterus