Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased activity of surviving locus ceruleus neurons in Alzheimer's disease

1 Jan 1999

Abstract excerpt

In Alzheimer's disease (AD) there is neuronal loss in the locus ceruleus (LC), and the noradrenergic system may be even more affected in depressed AD patients. However, this neuronal loss may go together with an increase in activity of the remaining noradrenergic neurons. We prospectively evaluated 16 AD patients (6 depressed, 5 transiently depressed, and 5 nondepressed) and 10 controls. We determined...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Neurological Disease Mechanisms and Treatments
Share to Neuroscience and Neuropharmacology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9894881
DOI: 10.1002/1531-8249(199901)45:1<82::aid-art14>3.0.co;2-t

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Increased activity of surviving locus ceruleus neurons in Alzheimer's diseasePMID 9894881Read ↗

Locus ceruleus degeneration is ubiquitous in Alzheimer’s disease: Possible implications for diagnosis and treatmentSemantic proximity Read ↗

Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseasesSemantic proximity Read ↗

Locus Ceruleus Degeneration Promotes Alzheimer Pathogenesis in Amyloid Precursor Protein 23 Transgenic MiceSemantic proximity Read ↗

Locus coeruleus integrity is related to tau burden and memory loss in autosomal-dominant Alzheimer's diseaseSemantic proximity Read ↗

Locus coeruleus integrity is related to tau burden and memory loss in autosomal-dominant Alzheimer’s diseaseSemantic proximity Read ↗

Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleusSemantic proximity Read ↗

Early alteration of the locus coeruleus in phenotypic variants of Alzheimer’s diseaseSemantic proximity Read ↗

The Neurotoxin DSP-4 Dysregulates the Locus Coeruleus-Norepinephrine System and Recapitulates Molecular and Behavioral Aspects of Prodromal Neurodegenerative DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.