Article
Atherosclerosis in APOE*3-Leiden transgenic mice: from proliferative to atheromatous stage.
Circulation - 19 Jan 1999
Lutgens E, Daemen M, Kockx M, Doevendans P, Hofker M, Havekes L, Wellens H, de Muinck E D
Abstract excerpt
BACKGROUND: This study documents (1) the progression of atherosclerosis along the entire arterial tree in APOE*3-Leiden mice after 1, 4, 6, 9, and 12 months of a high-fat/high-cholesterol (HFC) diet and (2) the amount and phenotype of DNA-synthesizing and apoptotic cells in different lesion types...
Topics
- Animals
- Apolipoprotein E3
- Apolipoproteins E
- Apoptosis
- Arteriosclerosis
- DNA
- Diet, Atherogenic
- Disease Models, Animal
- Disease Progression
- Female
- Foam Cells
- Male
- Mice
- Mice, Transgenic
- Phenotype