Article
Accelerated atherosclerosis by placement of a perivascular cuff and a cholesterol-rich diet in ApoE*3Leiden transgenic mice.
Circulation research - 4 Aug 2000
Lardenoye J H, Delsing D J, de Vries M R, Deckers M M, Princen H M, Havekes L M, van Hinsbergh V W, van Bockel J H, Quax P H
Abstract excerpt
Intimal hyperplasia after vascular injury is usually studied in animal models with healthy, normocholesterolemic animals. Here, we assess the effect of diet-induced hypercholesterolemia on the induction of intimal hyperplasia in ApoE*3Leiden mice. A nonconstrictive polyethylene cuff was placed around the femoral artery of ApoE3*Leiden mice fed a highly cholesterol-rich diet, a mildly cholesterol-rich diet, or a...
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