Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Roles of phosphoinositide-dependent kinase-1 in α1B-adrenoceptor phosphorylation and desensitization.

European journal of pharmacology - 15 Jan 2012

Alcántara Hernández Rocío, García-Sáinz J Adolfo

Abstract excerpt

The role of phosphoinositide-dependent protein kinase-1 (PDK-1) activity on α(1B)-adrenoceptor phosphorylation and function was explored using pharmacological inhibitors and expression of a dominant-negative mutant of this enzyme. Noradrenaline-, phorbol myristate acetate-, lysophosphatidic acid- and epidermal growth factor-mediated α(1B)-adrenoceptor phosphorylation were markedly reduced by the two inhibitors...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3-Phosphoinositide-Dependent Protein Kinases
Share to Chlorocebus aethiops

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to COS Cells

Share to Cricetinae

Share to Intracellular Space

Share to Norepinephrine

Share to Receptors, Adrenergic, alpha-1

Share to Staurosporine

Source

Identifiers

PMID: 22134004
DOI: 10.1016/j.ejphar.2011.11.021

Genes

UCN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Roles of phosphoinositide-dependent kinase-1 in α1B-adrenoceptor phosphorylation and desensitization.PMID 22134004Read ↗

Identification of tyrosine phosphorylation sites on 3-phosphoinositide-dependent protein kinase-1 and their role in regulating kinase activity.Semantic proximity Read ↗

Phosphoinositide-dependent phosphorylation of PDK1 regulates nuclear translocation.Semantic proximity Read ↗

Regulatory properties of alpha(1B)-adrenergic receptors defective in coupling to phosphoinositide hydrolysis.Semantic proximity Read ↗

Roles of the phosphorylation sites of distinct α1A-adrenergic receptor domains.Semantic proximity Read ↗

Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1.Semantic proximity Read ↗

Regulatory mechanisms of alpha 1B-adrenergic receptor function.Semantic proximity Read ↗

Identification and characterization of the phosphorylation sites of the guanylyl cyclase-linked natriuretic peptide receptors A and B.Semantic proximity Read ↗

Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes.Semantic proximity Read ↗

Phosphorylation of CalDAG-GEFI by protein kinase A prevents Rap1b activation.Semantic proximity Read ↗

Phosphorylation of Galpha11 protein contributes to agonist-induced desensitization of 5-HT2A receptor signaling.Semantic proximity Read ↗

Sequential protein kinase C (PKC)-dependent and PKC-independent protein kinase D catalytic activation via Gq-coupled receptors: differential regulation of activation loop Ser(744) and Ser(748) phosphorylation.Semantic proximity Read ↗

Role of FK506 binding protein 12 in morphine-induced μ-opioid receptor internalization and desensitization.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.