Article
A non-classical ISRE/ISGF3 pathway mediates induction of RANTES gene transcription by type I IFNs.
FEBS letters - 30 Jan 2002
Cremer Isabelle, Ghysdael Jacques, Vieillard Vincent
Abstract excerpt
RANTES (regulated upon activation normal T cell expressed and secreted) is a chemoattractant cytokine important in the generation of inflammatory responses and human immunodeficiency virus resistance. In hematopoietic cells, RANTES is over-expressed by type I interferons (IFN-alpha and IFN-beta). The upstream region of the RANTES gene promoter contains a distal low affinity IFN-stimulated response element (ISRE)....
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