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Article

Pathophysiology of the MELAS 3243 transition mutation.

The Journal of biological chemistry - 24 Oct 1997

Flierl A, Reichmann H, Seibel P

Abstract excerpt

Single base substitutions of the mitochondrial genome are associated with a variety of metabolic disorders. The myopathy, encephalopathy, lactic acidosis, stroke-like episodes syndrome, most frequently associated with an A to G transition mutation at position 3243 of the mitochondrial tRNALeu(UUR) gene, is characterized by biochemical and structural alterations of mitochondria. To investigate the pathophysiology...

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Identifiers

PMID: 9341162
DOI: 10.1074/jbc.272.43.27189

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Pathophysiology of the MELAS 3243 transition mutation.PMID 9341162Read ↗

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