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Article

Aggregation gatekeeper and controlled assembly of Trpzip β-hairpins.

Biochemistry - 25 Feb 2014

Markiewicz Beatrice N, Oyola Rolando, Du Deguo, Gai Feng

Abstract excerpt

Protein and peptide aggregation is an important issue both in vivo and in vitro. Herein, we examine the aggregation behaviors of two well-studied β-hairpins, Trpzip1 and Trpzip2. Previous studies suggested that Trpzip2 remains monomeric up to a concentration of ~15 mM whereas Trpzip1 readily aggregates at micromolar concentrations at acidic or neutral pH. This disparity is puzzling considering that these two...

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PMID: 24498924
DOI: 10.1021/bi401568a
PMCID: PMC3985754

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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