Article
The molecular basis of isolated 17,20 lyase deficiency.
Endocrine research - 1 Jan 2000
Miller W L, Geller D H, Auchus R J
Abstract excerpt
Human P450c17 catalyzes the 17alpha-hydroxylation of pregnenolone to 17OH pregnenolone and of progesterone to 17alpha-OH progesterone; the same P450c17 enzyme also catalyzes 17,20 lyase activity on the same active site, converting 17OH-pregnenolone to DHEA. Rodent and porcine P450c17 also catalyz...
Topics
- Adrenal Hyperplasia, Congenital
- Binding Sites
- Humans
- Mutation
- Oxidation-Reduction
- Steroid 17-alpha-Hydroxylase