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Article

The molecular basis of isolated 17,20 lyase deficiency.

Endocrine research - 1 Jan 2000

Miller W L, Geller D H, Auchus R J

Abstract excerpt

Human P450c17 catalyzes the 17alpha-hydroxylation of pregnenolone to 17OH pregnenolone and of progesterone to 17alpha-OH progesterone; the same P450c17 enzyme also catalyzes 17,20 lyase activity on the same active site, converting 17OH-pregnenolone to DHEA. Rodent and porcine P450c17 also catalyze 17,20 lyase activity with delta4 substrates, converting 17OH-progesterone to delta4 androstenedione, but human...

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Identifiers

PMID: 9888582
DOI: 10.3109/07435809809032692

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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